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doi: 10.1016/S0140-6736(17)32448-0, 28

This so-called Na-RALA is significantly more bioavailable (Studies on comparable products have shown a 21-fold increased bioavailability (determined) as a simple, unstabilized R-alpha lipoic acid, as measured by the maximum blood plasma concentration (Cmax), and is also 100% free of S-alpha lipoic acid

Furthermore, in the tumor microenvironment, lactate can polarize macrophages toward a pro-angiogenic phenotype characterized by vascular endothelial growth factor (VEGF) production, which facilitates tumor progression [107]