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La conversin de metilmalonil CoA a Succinil-CoA implica a la adenosilcobalamina como cofactor, habiendo en caso de deficiencia de sta una acumulacin del cido metilmalnico

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This master antioxidant is naturally produced in the body, primarily in the liver

Patients with vitamin B6 deficiency typically show insensitivity to antiseizure medications but respond well to treatment with PN, and there is a clear dose-dependent relationship [6]

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