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A preclinical study of HCC demonstrated that olaparib upregulates PD-L1 via the suppression of microRNA-513, and its combination with anti-programmed cell death protein-1 (PD-1) therapy significantly enhances CD8+T-cell infiltration and antitumor efficacy (100)

COPD induces profound metabolic disturbances in lung macrophages ( Figure 4 )

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Figure 1: Changes in A) systolic diameter, B) diastolic diameter, C) septal thickness in systole, D) posterior wall thickness in systole, and E) left ventricle ejection fraction