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Insufficient human clinical trials have led to a lack of data to determine a safe dose

In the case of vitamin B 12 there is no UL, as there is no human data for adverse effects from high doses

[15] [16] NICE guidance (CG189: Obesity identification, assessment and management, and PH53: Weight management lifestyle services) supports the use of total diet replacement programmes only within structured clinical settings with appropriate monitoring and multidisciplinary support

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