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Abbreviations AD: Alzheimers disease ALA: -Linolenic acid ALS: Amyotrophic lateral sclerosis APP: Amyloid precursor protein ARA: Arachidonic acid A: Amyloid beta BBB: Bloodbrain barrier BDNF: Brain-derived neurotrophic factor COX-2: Cyclooxygenase 2 DHA: Docosahexaenoic acid EGCG: Epigallocatechin-3-gallate EPA: Eicosapentaenoic acid FOS: Fructooligosaccharides GC: Gas chromatography GPCRs: G-protein-coupled receptors IL: Interleukin iNOS: Inducible nitric oxide synthase LA: Linoleic acid LC: Liquid chromatography LPS: Lipopolysaccharide LTB: Leukotrienes B MAPK: Mitogen-activated protein kinase NADPH: Nicotinamide adenine dinucleotide phosphate NDD: Neurodegenerative diseases NEP: Neprilysin NF-B: Nuclear factor kappa B NMDAR: N-methyl D-aspartate receptor NOX-2: NADPH oxidase 2 Nrf2: Nuclear factor erythroid 2-related factor 2 PD: Parkinsons disease PGE2: Prostaglandin E PUFA: Polyunsaturated fatty acid ROS: Reactive oxygen species SCFA: Short-chain fatty acid SIRT1: Sirtuin-1 ThB: Thromboxane TLR-4: Toll-like receptor-4 TNF-: Tumor necrosis factor-alpha References Winter AN, Bickford PC

In senescent cells, p53 is often sequestered in the nucleus by FOXO4

Although studies are scarce, here we discuss current knowledge on the underlying molecular pathways and provide a helpful review for further research and molecular targeting

BRD4, Bromodomain-containing protein 4

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