macule melanotic Labial Melanotic macule. Benign. Dark spot

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gingivalis LPS induces the expression of TLR4 and inflammatory cytokines and activates the NF-B signaling pathway (Kim et al., 2018)

Clinical and experimental data indicate that the integrity of BBB is progressively compromised with advancing age, depending on two ongoing parallel processes: the damage to brain ECs, resulting in metabolic and structural changes (endothelium-centered processes), and the remodeling of the neurovascular unit (neurovascular unit-centered processes) (Andjelkovic et al., 2023)

Thymoquinone inhibits epithelial-mesenchymal transition in prostate cancer cells by negatively regulating the TGF-/Smad2/3 signaling pathway

Acute hyperglycemia exacerbates neuroinflammation and cognitive impairment in sepsis-associated encephalopathy by mediating the ChREBP/HIF-1 pathway