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Polyphenols have the capacity to bind to transition metal ions such as iron and copper

In addition, it is difficult to determine which patients are suitable for targeted therapy, and this process requires the use of biomarkers

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This effect is mechanistically distinct from galangin, which suppresses aberrant NLRP3 activation in ovarian cancer xenograft mouse models, downregulating both NLRP3 expression and IL-1 maturation ( 3.4.2 Inhibition of the NF-B pathway Nuclear factor-B (NF-B) is a transcription factor highly associated with inflammation, mainly composed of the p65 subunit and the p50 subunit

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