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The efficacy of lorcaserin appears similar to that of orlistat (mean difference in weight loss between active and placebo treated groups approximately 3 to 4 kg) and perhaps slightly less than that of phentermine-topiramate

[5] In summary, pyridoxine may decrease the efficacy of certain medications (notably levodopa and some anticonvulsants), and various drugs can in turn precipitate vitamin B deficiency

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Short courses of doxycycline are now considered safe for children of all ages when clinically indicated, as the risk of tooth staining with brief use is minimal

Older adults and vegetarians may benefit from a vitamin B12 supplement or an increased intake of foods fortified with vitamin B12

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