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APOC1 inhibition reverses the M2-to-M1 phenotype shift in TAMs through the ferroptosis pathway, resulting in decreased relative proportions of M2 macrophages, B cells and CD4 + T cells, and increased relative proportions of CD8 + T cells, M1 macrophages and NK cells, thereby remodeling the tumor immune microenvironment [243]

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In the case of the C-terminal region of nsp3, we therefore consider Y1 with its subdomains Y1a and Y1b as one domain

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