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1 Introduction After their discovery in the mid of the 19th century, for over a century astrocytes were considered that substance which lies between the proper nervous parts, holds them together and gives the whole its form in a greater or lesser degree (quoted from a Rudolf Virchows lecture, 3 April 1858)

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assessed the metabolic reprogramming in tumors and found that metabolic signals were cross-linked between PDAC and CAFs

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MAT2A inhibitors AG-270 and IDE-397 have demonstrated significant antitumor activity both in vitro and in animal models, and phase I clinical trials are currently underway