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Until recently, the majority of FDA-approved AD drugs on the market include cholinesterase inhibitors and a single NMDA antagonist, which solely tackle the symptoms of AD and neglect the underlying mechanisms of the disease (Wang and Reddy, 2017

Both conditions involve degenerative changes to the tendons that attach forearm muscles to the bony prominences around the elbow joint

Cuproptosis increases the stability of NFE2L2 by suppressing its proteasomal degradation, leading to transcriptional upregulation of GCLC and GCLM and enhanced GSH synthesis, thereby suppressing cuproptosis in pancreatic cancer cells 169

To assess the status of RhoA and its activation in cardiac junctions, we employed the well-established TCA fixation method that allows for the visualization of junctional-specific endogenous RhoA by immunofluorescence (21, 22)

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Lancet Digital Health 2, e286e287