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(2004) J.Recept.Signal.Transduct.Res

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Furthermore, inhibiting TLR4 can also modulate gut microbiota homeostasis and the MyD88/NF-B axis in ulcerative colitis (164), indicating that TLR4 acts not only as a key sensor of innate immunity but may also regulate neuroimmune crosstalk and gut microenvironment homeostasis

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These agents are useful in treatment of metastatic kidney cancer, but as for other anticancer drugs, resistance develops with continued use, through mechanisms not yet fully defined

Similar experiments using watermelon rinds, an agricultural biowaste rich in L-citrulline have corroborated these findings [94, 95]