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4 Levels below 150 pmol/L (203 pg/ml) are classified as low and can cause permanent neurological damage and fetal abnormalities in babies of untreated mothers

The reference intervals may vary between laboratories

Used to reduce high cholesterol, it also helps reduce risk of heart disease, infertility, circulation, brain disorders like Rett Syndrome, chronic fatigue syndrome, diabetes, overactive thyroid, ADHD, and improve athletic performance and endurance

Where they diverge is what they are and where they sit on the regulatory ladder

Dec2025;87(12):7868-7869

This is an important enzyme of the folate pathway that maintains the methyl pool required for regulatory functions and conversion of a form of folate called 5,10-methylenetetrahydrofolate to a different form of folate called 5-methyltetrahydrofolate