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Furthermore, in MM, a subpopulation of regulatory T cells (Tregs) shows increased CD38 expression compared to T constitutive cells (Tcons), which enhances their immunosuppressive effect

For this reason, treatment should be based on a thorough medical evaluation, appropriate laboratory testing, proper dosing, and ongoing monitoring by a qualified healthcare provider

Peterson LW, Artis D (2014) Intestinal epithelial cells: regulators of barrier function and immune homeostasis

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Anticipate the need for a platelet transfusion once the platelet count drops to a very low value