Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-PNP snap which binds to DCAF1 with

which binds to DCAF1 with a Kd by SPR and IC50 by TR-FRET of <50 nM

Product Name CA-PhN3 Synonyms Azidobenzoyl-Halo

NCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

933 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Pomalidomide-PEG2-C2-acid Synonyms Pomalidomide-4'-PEG2-C2-acid CAS Number 2140807-17-4 Related CAS Molecular Formula C20H23N3O8 Molecular Weight 433

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-PNP snap which binds to DCAF1 withSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating