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For research purposes, TB-500s smaller size offers practical advantages over full-length T4 in terms of synthesis, cost, and stability , while its focused representation of the active actin-binding domain makes it a useful tool for studying the actin dynamics-dependent aspects of thymosin beta-4 biology specifically, without the potential contributions of other functional regions present in the full-length molecule

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However, we acknowledge that studies with conflicting or non-replicable findings are equally important and should be included in comprehensive future analyses