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Oxidative Stress & Detoxification Burden: Toxins from the pathogens themselves, as well as byproducts of the immune response, can overload the bodys detox pathways (especially liver and lymphatic systems), leading to cellular damage and inflammation

This intriguing hypothesis awaits formal validation and is not fully corroborated by epidemiological evidence [35]

In cell culture models of human macrophage foam cells, the inability to clear cholesterol from macrophages with compromised lysosome function continues even in the presence of compounds that stimulate efflux (161,163)

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Given the current guidelines and the incidence of herpes zoster in patients receiving TNF alpha inhibitors, clinicians should strongly consider vaccination before starting therapy

First, the crosstalk network between distinct ferroptosis-regulating pathways (System Xc GSHGPX4 axis, lipid peroxidation, iron metabolism, and epigenetic regulation) remains poorly definedwhether these pathways act in a hierarchical, synergistic, or compensatory manner in different phases of I/R injury (ischemia vs