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The Billon 2025 paper (PMID 41421047) introduced SLU-PP-915 as an "orally active" sibling specifically because the parent SLU-PP-332 "lacks oral bioavailability." Despite that, the most common vendor formats are oral capsules and tablets products without published evidence that they produce systemic ERR agonism in humans

the contents are 3x as much as in a normal shot which is just likely to be excessive and result in more being flushed down the lavatory as the rate of loss is higher if you have more in your blood so more isn't necessarily better - and they are also suggesting a really high frequency of use which is also likely to be unnecessary

An over-the-counter pill has to survive digestion, and the body absorbs only a small fraction of it

Thus, for many patients it solves two problems at once

If a patients mitochondria are not effectively converting stored fat into usable energy, blocking their appetite will only result in fatigue and muscle catabolism