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Approximately 64.0 22.8% of the toxin dose is excreted renally in its unmodified form or as a glucuronic acid conjugate (Warth et al

The notion that neoantigens significantly contribute to immunogenicity in the majority of malignancies is supported by the finding that TMB has proven a reliable predictor of immunotherapy response, both within and across tumor types [63, 92,93,94]

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