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Vlachakis D, Mitsis T, Nicolaides N, et al

The rationale is that glucagon also increases energy expenditure and promotes hepatic fat mobilization, so a molecule that combines glucagons metabolic-rate effect with GLP-1/GIPs appetite-and-glucose control can, in principle, drive weight loss from both sides of the energy-balance equation at once

An estimated 1.8 million adult New Yorkers (11.3%) have diagnosed diabetes

These separate, but related mechanisms of action of an amylin-analog and a GLP-1 receptor agonist appear to have an additive effect on appetite reduction

Carpentier, A

Neurotrophins: transcription and translation