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Microbiome differences were greater between the two groups switched from WD to LD (i.e., WD/LD-V and WD/LD-T) and the two diet control groups (i.e., LD/LD-V and WD/WD-V) compared to the microbiome differences observed between the lean (LD/LD-V) and obese (WD/WD-V) control groups

This metabolic improvement occurs through AMPK pathway activation and increased NAD+-dependent SIRT1 activity, both of which enhance insulin receptor signaling and glucose metabolism

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Materials and Methods Research Materials Select representative glacial and non glacial animals as research subjects

Understanding both its short-term and long-term effects is essential before considering its use

Cell Metab (2015) 22(1):3153