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& Guan, H

Similarly, MRTX849 treatment decreased intratumoural immunosuppressive myeloid-derived suppressor cells and M2-polarised macrophages and increased immune-promoting M1-polarised macrophages, dendritic cells, and CD4 + and NKT cells in KRAS (G12C) tumours by altering the expression of tumour RNA and protein implicated in the presentation of tumour antigens or mediating an immunosuppressive TME 204

Immune checkpoint inhibitors and ferroptosis inducers have been shown to work in concert in preclinical models to enhance anti-tumor immunity and cancer cell death (Cai et al