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Cigarette smoke exposure followed by DSS-induced colitis resulted in significantly greater weight loss, higher clinical scores, shorter colon lengths, and more severe pathological and endoscopic assessments in Gpr15 / mice than in Gpr15 +/+ mice (Fig

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Once inhaled, nicotine reaches the brain within a few seconds, generally between 10 and 20, and promptly stimulates nerve receptors, triggering the production of dopamine, the neurotransmitter responsible for the sensation of pleasure and reward