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Evaluation of oxidant and intracellular anti-oxidant activity in rheumatoid arthritis patients: In vivo and in silico studies

To address the ROS burst driven by ferroptosis and the imbalance of iron homeostasis, a study has developed a macrophage-targeting polysaccharide iron nanoenzyme, which possesses dual enzyme activities resembling catalase and peroxidase, capable of scavenging ROS, inhibiting lipid peroxidation, and controllably releasing Fe 2 to correct systemic iron deficiency [150]

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There is a very strong body of experimental evidence indicating a neuroprotective role of UA, mediated through anti-inflammatory and antioxidative mechanisms that themselves are likely to be closely interrelated (summarised in Fig

have shown that MZB display increased sensitivity to lipid peroxidation in Gpx4 -deficient mice 33

Cellular adaptation mediated through Nrf2-induced glutamate cysteine ligase up-regulation against oxidative stress caused by iron overload in beta-thalassemia/HbE patients