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In summary, this section not only untangled the diverse molecular mechanisms by which small molecules target the regulation of MMPs to inhibit GBM invasion (involving key signaling pathways, metabolism, non-coding RNAs and ion channels), but also highlighted the considerable clinical translational potential of certain compounds [such as NP16 and novel Pt(IV) complexes] with excellent BBB penetration and in vitro/in vivo activity in overcoming GBM invasiveness (Table SIII)

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Repeated measures ANOVA, followed by Bonferronis post hoc test, was used to assess changes over time