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Therefore, ROS production upon antigen stimulation of TCR promotes TCR signaling and transcriptional activation of IL-2 ( Figure 2 )

doi: 10.3389/fmicb.2021.698169 169 ThompsonEJWilliamsDMWalkerAJMitchellRENiedzwiedzCLYangTCet al

However, oral supplementation may be limited by: Gastrointestinal intolerance Malabsorption syndromes Nausea or reduced appetite Medication-related absorption changes IV B-complex: Bypasses gastrointestinal absorption Allows predictable uptake Can be combined with hydration and other supportive nutrients May be considered when oral options are ineffective or poorly tolerated When B-Complex IV Therapy May Be Appropriate B-complex IV therapy is not intended for routine or indefinite use

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2.3 Dosing in Patients Taking Rufinamide Patients stabilized on rufinamide before being prescribed valproate should begin valproate therapy at a low dose, and titrate to a clinically effective dose [see Drug Interactions (7.2) ]